The maximum likelihood estimations of multi-sample time series with both equally and unequally spaced data are discussed in detail. Furthermore, the formulas of point estimation and confidence interval estimation are introduced when upper and lower limits of P-T curve are assumed. 具体给出了等间距与非等间距情形下多样本P-T曲线模型参数的极大似然估计方法以及当给定压强满足可靠性要求的上、下限时可靠度的点估计与区间估计计算公式。